python convert integer to signed base 2 complement
def twos_comp(val, bits):
"""compute the 2's complement of int value val"""
if (val & (1 << (bits - 1))) != 0: # if sign bit is set e.g., 8bit: 128-255
val = val - (1 << bits) # compute negative value
return val # return positive value as is
binary_string = '1010101010' # or whatever... no '0b' prefix
out = twos_comp(int(binary_string,2), len(binary_string))