To convert an Excel file to PDF, simply operate Excel from win32com
import win32com.client from pywintypes import com_error # Path to original excel file WB_PATH = r'C:\hoge\fuga\YearCalendar.xlsx' # PDF path when saving PATH_TO_PDF = r'C:\hoge\fuga\YearCalendar.pdf' excel = win32com.client.Dispatch("Excel.Application") excel.Visible = False try: print('Start conversion to PDF') # Open wb = excel.Workbooks.Open(WB_PATH) # Specify the sheet you want to save by index. 1 is the first (leftmost) sheet. ws_index_list = [1,2,3,4,5,6,7,8,9,10,11,12] wb.WorkSheets(ws_index_list).Select() # Save wb.ActiveSheet.ExportAsFixedFormat(0, PATH_TO_PDF) except com_error as e: print('failed.') else: print('Succeeded.') finally: wb.Close() excel.Quit()